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Phytoconstituents, Cytotoxic, Antioxidant and Hepatoprotective Activities of the Aerial Parts of Lycium shawii R. Growing in Egypt

Ahmed Gaweesh, Abd El-Naser Badawi Sengab, Hala Mohamed El- Hefnawy, Samir Mohamed Osman and Ahmed Muhammed Abdou

The fruit and decoction of Lycium shawii Roem and Schult (Solonaceae) aerial parts are used to prevent from liver damage in folk medicine. In the present study biological activities and phytochemical study of aerial parts of Lycium shawii R. Family Solanaceae were evaluated. Methylene chloride fraction exhibits potent inhibition of cell growth against MCF7 cancer cell. Ethyl acetate fraction has the highest radical scavenging activity as determined by DPPH assay. Ethyl acetate fraction showed the highest hepatoprotective activity against CCL4- induced hepatotoxicity compared to standard silymarin. Phytochemical study of bio-active fractions (Methylene chloride and Ethyl acetate) of L. Shawii R. resulted in isolation and structural determination of 5 compounds; 5,9-Heneicosadienoic acid methyl ester, β-Sitosterol, Atropine, Trans-Ferulic acid and 5- Hydroxy Ferulic acid.