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Inactivated Probiotic Bacillus coagulans GBI-30 Demonstrates Immunosupportive Properties in Healthy Adults Following Stressful Exercise

Douglas S Kalman and Susan Hewlings

Objective: Probiotics have been associated with many health benefits and have an established safety record. The purpose of this pilot study was to determine the safety and efficacy of inactivated Bacillus coagulans GBI-30, 6086 (Staimune®) in supporting the immune system at rest, in response to an in vitro bacterial challenge, and in response to strenuous exercise.
Methods: In a randomized double-blind placebo-controlled pilot study, 16 healthy adults received either Staimune® or Placebo over 28-d. Basal immune system was assessed (salivary IgA, complete blood count with differential, helper T-cell (CD3+/CD4+), cytotoxic T-cells (CD3+/CD8+), and natural killer cells (CD3-/56+ or CD3-/16+/56+) percentages/proportions. In addition, cytokine (IL-1b, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p70), IL-13, IFN gamma, GM-CSF, and TNF-a) in response to an in vitro lipopolysaccharide challenge as well examining basal serum cortisol values. Subjects performed 60-min treadmill running at 60-80% of their Karvonen predicted max heart rate. Blood and salivary samples were also collected at 10, 60, and 120-min post-exercise. Data analysis was based upon changes over time relative to baseline for within group changes as well as between-group differences (P<0.05), 95% CI.
Results: Both conditions supported mucosal immunity. Ten minutes after exercise WBC was significantly greater in the Staimune group vs. Placebo, no difference between groups at 60 or 120-min. Neutrophils and Monocytes were significantly greater in the Study Product group. There were variable impacts on eosinophils and basophils. Markers of non-specific and innate immunity were significantly impacted in Staimune® as were the impacts on pro and anti-inflammatory cytokines. There was significantly enhanced recovery for cortisol in the Staimune® group in the post-exercise period.
Conclusion: Inactivated Bacillus coagulans GBI-30, 6086 supports the immune system at rest and after strenuous exercise. The study product may lessen the window of immune system suppression post-exercise, and enhance stress recovery supporting immunity.