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Does 11β-HSD1 Associate with the Development of Visceral Adiposity in Maternal Mg Restricted Wistar/NIN Rat Offspring?

Kalashikam Rajender Rao, Inagadapa Padmavathi, Lagishetty Venu and Manchala Raghunath

Maternal magnesium restriction irreversibly increased body fat %, specially the visceral adiposity in WNIN rat offspring. We have now investigated whether the increased visceral adiposity was associated with increased adipogenesis and glucocorticoid stress. Female, weanling WNIN rats were fed for 12 weeks, a control (AIN 93G) diet (MgC) or the same with 70% restriction of Mg (MgR) and mated with control males. Some of the pregnant MgR dams were rehabilitated from parturition and their pups weaned on to control diet (MgRP). At weaning half of the pups from MgR dams were shifted to control diet (MgRW) while the other half continued on Mg restriction (MgR). mRNA expression for fatty acid synthase (FAS) and 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) was significantly higher in MgR adipose tissue offspring. However leptin mRNA expression was comparable among different groups. Both the rehabilitation regimes corrected the expression of 11β-HSD1 but not that of FAS. Maternal Mg restriction predisposed the offspring to increased glucocorticoid stress (11β-HSD1) that could underlie the increased body fat %/central adiposity.