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A Novel Herbal Formulation (Glymin Sprinkle) Enriched with Multigrain Inhibits Oxidative Stress, AGE Formation and Pancreatic Pathology Associated with Diabetes

Sheethal S, Ratheesh M*, Svenia P Jose, Asha S, Sandya S, Sony Rajan, Sarala Samuel

Background: Diabetes is a multifactorial, heterogeneous metabolic disorder with micro and macro vascular complications that results in noteworthy concerns in human life and its treatment has also become more challenging due to the adverse effect of current medicines. In this scenario, the use of dietary food supplements is most advocated, because it’s mainly derive from medicinal plants, fruits, vegetables and grains.

Objective: The present study aimed to investigate the effect of novel herbal formulation (Glymin sprinkle) enriched with multigrain inhibits oxidative stress, AGE formation and pancreatic pathology associated with diabetes.

Methods: Herein, we report the effect of novel herbal formulation [Glymin sprinkle (GS)] enriched with multigrain on Streptozotocin induced diabetic model. Diabetes was induced by a single dose of Streptozotocin (60 mg/kg b.wt) injection through intra-peritoneum. Efficacy of GS was determined by analysing various parameter like antioxidants status, liver enzyme markers, glycation of haemoglobin, blood glucose level, glyoxalase-1 protein expression, histological analysis were analysed.

Results: From the results, it strongly supported that GS significantly enhance the antioxidant status, glyoxalase 1 expression and maintain the normal structure of pancreas. Also, it helped to reduce the overwhelmed blood glucose level, liver enzymes and glycated haemoglobin.

Conclusion: All these results suggested that GS has potent anti-diabetic effect. Thus, it can be recommended to diabetic patients.