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Treatment Response in Dogs with Naturally Occurring Grade 3 Elbow Osteoarthritis Following Intra-Articular Injection of 117mSn (Tin) Colloid: A Revie

John Donecker, Michelle Fabiani, Lorrie C, Karanvir Singh Aulakh

The radionuclide 117mSn (tin-117m) embedded in a homogeneous colloid is a novel Radio Synovi Orthesis (RSO) device for Intra-Articular (IA) administration to treat synovial inflammation and mitigate Osteo Arthritis (OA) in dogs. A study to evaluate tin-117m colloid treatment response in dogs with OA was conducted at two centers, the School of Veterinary Medicine at Louisiana State University, and at a referral practice in Houston, Texas. The tin-117m colloid was administered per-protocol to 14 client-owned dogs with radio graphically confirmed grade 3 OA in one or both elbow joints. Dog owners and attending clinicians assessed the level of pain at Base Line (BL) and the posttreatment pain response at 90-day intervals for one year. Owners assessed treatment response according to a Pain Severity Score (PSS) and a Pain Interference Score (PIS) as defined by the Canine Brief Pain Inventory. Clinicians reported a lameness score using a 0-5 scale, from no lameness to continuous non-weight bearing lameness, when observing dogs at a walk and a trot. The rate of treatment success as determined by improved mean PSS and PIS scores reported by dog owners was >70% at all-time points. Clinicians reported an improved mean pain score from BL at post-treatment Days 90 (p<0.05), 180, and 270. The dog owner and clinician assessments of treatment success were significantly correlated (p>0.05) at Day 90 and Day 180 time points. Results indicated that a single IA dose of tin-117m colloid provided a significant reduction in pain and lameness and improved functionality for up to a full year, with no adverse treatment related effects, in a high percentage of dogs with advanced, clinical OA of the elbow joint.