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Pharmaco-Informatics: Homology Modelling of the Target Protein (GP1, 2) for Ebola Hemorrhagic Fever and Predicting an Ayurvedic Remediation of the Disease

Preenon Bagchi, Mahesh. M and Somashekhar.R

Ebola hemorrhagic fever (Ebola HF) is caused by inf ection with Ebola Virus. Ebola virus, a member of t he family Filoviridae , causes one of the most severe forms of viral hemo rrhagic fever. In the final stages of the disease, symptoms progress to hypotension, coagulat ion disorders, and hemorrhages, and there is promin ent involvement of the mononuclear phagocytic and retic ulo-endothelial systems. It is assumed that the fun ctions of the envelope glycoprotein are likely to play import ant roles in the pathogenicity of Ebola virus and t he interac- tions of some viral proteins with the immune system are likely to play important roles in the extraord inary pathogenicity of this virus. Ebola virus (EBOV) ent ry requires the surface glycoprotein (GP) to initia te attach- ment and then fusion occurs between viral and host membranes. All glycoprotein forms are encoded by ge ne 4 of the EBOV genome. The strain selected is VGP_EBOS U with accession number Q7T9D9 of Sudan Ebola Virus - Uganda (2000) from NCBI’S entrez database. The 3D structure of Ebola Virus Protein was generat ed using Homology Modelling. For a predicted evaluatio n Andrographolide is used (the compound needs clini cal trials to prove its efficacy in treatment). The 3D structure of Andrographolide was generated and was converted to *.pdb file which now docks with the *.pdb file o f Ebola Virus Protein.