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High-Sensitivity Cardiac Troponin T is Associated with SYNTAX Score and Diabetes Mellitus in Patients with Stable Coronary Artery Disease

Hakan Uçar, Mustafa Gür, Taner Seker, Onur Kaypakli, Zafer Elbasan, Nermin Yildiz Koyunsever, Caner Türkoglu, Betül Özaltun, Osman Kuloglu, Gülhan Yüksel Kalkan, Durmus Yildiray Sahin and Murat Çayli

High-sensitivity cardiac troponin T (hs-cTnT) and the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score are emerging as important prognostic markers in stable coronary artery disease (CAD). We aimed to investigate the relationship between hs-cTnT and extent and complexity of CAD assessed with STNTAX score. Measurements were obtained from 411 patients with stable CAD (Mean age=61.7 ± 9.9 years, male/female=247/164). The patients were divided into two groups according to the median hs-TnT value (hs-cTnTlow group<9.65 pg/ml and hs-cTnThigh group ≥ 9.65 pg/ml). SYNTAX score values were higher in hs-cTnThigh group compared with hs-cTnTlow group (p<0.05). Hs-cTnT was independently associated with SYNTAX score (β=0.661, p<0.001) and diabetes (β=0.107, p=0.031) in multiple linear regression analysis. The cutoff value of hscTnT obtained by the ROC curve analysis was 9.62 ng/L for the prediction of higher SYNTAX score. In multivariate logistic regression analysis, hs-cTnT, age, diabetes, creatinine and hs-CRP were an independent predictor for higher SYNTAX score. Despite very low circulating concentrations, changes in hs-cTnT concentrations are associated with extent and complexity of CAD and presence of diabetes in patients with stable CAD.