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Anti-convulsant action and amelioration of oxidative stress by ethanolic extract of aerial parts of Muehlenbeckia platyclada

PRIYAKUMAR ANCY, PADMAJA V, NITHINMANOHAR R, RAJKUMAR R, SHIJIKUMAR P S

Muehlenbeckia platyclda is a medicinal plant which contains quercetin, kaemferol and luteolin and it is used to treat a wide range of disorders including seizure. However, the anticonvulsant activity of this plant has not been studied. We therefore sought to evaluate the anticonvulsant activity of ethanolic extract of M. platyclada aerial parts. Phenyl tetrazole (PTZ) induced convulsion, maximum electro shock (MES) induced convulsion and 6Hz induced convulsion were carried out for screening anticonvulsant activity. The extract was effective in controlling the seizures and its ED 50 value was calculated. It was evident from the studies that the M.platyclada extract had marked anticonvulsant activity. Further experiments will be required to identify the active molecules(s) and their mechanism(s) of action.