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Upgrading of Lethal Dose of Tetrapleura tetraptera Extract Enhances Blood Cell Values

Jimmy EO, Ekpo AJD

Effects of aqueous extract of Tetrapleura tetraptera (Uyayak) on blood cells were investigated in 28 albin rats for the period of 28 days. The acute toxicity LD50 on 30 albino mice was 244.94 mg/kg. The red blood cells counts increased at 40% of the LD50 extract on day 14, 30% of LD50 on day 21 and at 10% of the LD50 on day 28, (P<0.05). Platelets counts increased at 20% of LD50 on day 14, 40% LD50 on day 21 and 20% of LD50 on day 28 (P<0.05) total white blood cells counts increased at 40% of the LD50 on day 14, at 10% of LD50 on day 21 and at 20% of the LD50 on day 28, (P<0.05). The lymphocytes differential counts increased at 40% of the LD50 extract on day 14, at 10% of the LD50 on day 21 and at 20% of the LD50 on day 28 (P<0.05). Neutrophil different counts increased at 20% of the LD50 extract on day 14, at 40% of the LD50 on day 21 and at 30% of the LD50 on day 28. Mean corpuscular haemoglobin concentration (MCHC) increased at 20% LD50 on day 14, at 10% LD50 on day 21 and at 20% LD50 on day 28. Also the mean corpuscular haemoglobin, (MCH) increased at 20% LD50 on day 14, at 10% LD50 on day 21 and at 20% LD50 on day 28. The mean corpuscular volume, (MCV) increased at 20% LD50 on day 14, at 10% LD50 on day 21 and at 20% LD50 on day 28. It is shown in the study that extract of Tetrapleura tetraptera is a potent stimulant for blood cells development and should be adopted as haematinic.