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Therapeutic and Antioxidant Potential in the Shell Extract of Prunus amygdalus against Dermal Mycosis

Nasreen Thebo, Wazir Sheikh, M. Iqbal Bhangar, Pervaiz Iqbal and M. Hassan Nizamani

Mycosis is a common harmful problem for health throughout the world. Ringworm infection is one of the most dermatomycoses caused by species of pathogenic fungi such as Epidermatophyton, Trichophyton and Microsporum. The potential of biotechnology is to provide health protection through medicinal plants because it also facilitates the earlier detection of various ailments by new biotechnological techniques. Almond posses a variety of benefical properties affecting most notably cancer, high blood pressure, infectious disease and diabetes. In our study, we have used first time Almond hard shell extract for the evolution of antioxidant, antimicrobial potential and therapeutic efficacy against dermatomycosis pathogenic fungi. The extract was prepared by soxhlet method and TPC in the extract was determined by spectrophotometerically. The antioxidant activity of crude extract of almond shell was evaluated by using DPPH (2-2-diphenyl-1-picryhydrazyl) and radical scavenging system. The Minimum Inhibition Concentration (MIC) of extract was determined by well method against isolated pathogenic causative organisms for confirmation. The possibility of short term therapy was only 15 days. The total antioxidant activity varied from 93.32 to 94.40% and total phenolic content was found 3.422 mg/gm in almond shell extract. Hard shell extract of almond was found to be most effective as an antifungal and antibacterial agent against human pathogenic. Finally the results provide a therapeutic potential for microbial infections.