select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='49210' and ad.lang_id='8' and j.lang_id='8' and vi.lang_id='8' Human Leukocyte Antigen-G and Certain Auto-antibodies Profil | 49210
क्लिनिकल और सेलुलर इम्यूनोलॉजी जर्नल

क्लिनिकल और सेलुलर इम्यूनोलॉजी जर्नल
खुला एक्सेस

आईएसएसएन: 2155-9899

अमूर्त

Human Leukocyte Antigen-G and Certain Auto-antibodies Profile in Inflammatory Bowel Disease Patients

Hammadi A Alhilali, Osama T Alobaidy and Abdul-Razzaq A Tahir

Inflammatory Bowel Disease (IBD) is a chronic inflammatory disorder of the bowel represented by two major forms; Ulcerative colitis (UC) and Crohn’s disease (CD). The idiopathic nature of this disease manifests due to irregular intestinal mucosal immune-tolerance. The present study evaluates a possible genetic predisposing factor of the soluble Human Leukocyte Antigen-G (HLA-G) and estimates the auto-antibodies in the sera of a group of IBD Iraqi patients (38 with UC and 16 with CD) during Nov. 2010-Sep. 2011. The sera of the entire experimental group have been examined using commercial ELISA kits. A group of 21 apparently healthy individuals was also included as a control group in this study. The s.HLA-G and Anti-Elastase auto-antibody have found to be produced in all (100%) of CD patients compared with 18 (47.4%) and 24 (63.2%) of UC patients, for the two tests, respectively. Both assays haven’t shown positive result in healthy control sera. In addition to these two tests, the Anti-Cathepsin-G and Anti-Lysozyme auto-antibodies were found to be significantly differing in their prevalence among studied groups conferring diagnostic and differential tools. The positive/negative predictive values, sensitivities, and specificities of all tests have also been analyzed. The highest results were occurred in s.HLA-G and Anti-Elastase assays. These two factors were found to have an association with arthralgia development as an extra-intestinal manifestation among UC but not CD patients. The different expression levels of the studied parameters may aid in differential diagnosis and in following-up this group of patients.

अस्वीकरण: इस सार का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया था और अभी तक इसकी समीक्षा या सत्यापन नहीं किया गया है।
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