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Down Syndrome's Models of Human Nondisjunction and Mouse Models

Down Syndrome's Models of Human Nondisjunction and Mouse Models

Ttrisomy of human chromosome 21 (Hsa21) and Down syndrome (DS) is challenging to model in mice. Hsa21 (Orthologs) genes map to segments called Mmu16, Mmu17, and Mmu10. For DS Ts65Dn was the first viable segmental trisomy mouse model and it is a partial trisomy currently popular in preclinical evaluations of drugs for cognition in DS. Ts65Dn a limitations are as follows: (i) it is trisomic for 125 human protein-coding orthologs, but only 90 of these are Hsa21 orthologs (ii) it lacks trisomy for ~75 Hsa21 orthologs.