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अमूर्त

Prebiotic Inulin Alters the Colonic Mass, pH, Microflora and Short Chain Fatty Acids in 1,2-Dimethylhydrazine Dihydrochloride Induced Early Colon Carcinogenesis in Male Laca Mice

Geeta Shukla

Prebiotics have been found to have prophylactic potentials against colon cancer. Thus, the present study was designed to delineate the prophylactic role of prebiotics in experimental colon carcinogenesis. It was found that inulin+DMH-treated mice had significantly increased (p<0.05) body mass till 5th week and thereafter, decreased while in lactulose+DMH-treated mice the body mass increased significantly (p<0.05) from 5th week till end of experiment compared with DMH-only treated mice. Further, it was observed that mice belonging to inulin+DMH and
lactulose+DMH-treated groups had significantly (p<0.05) higher lactobacilli counts compared with DMH-only-treated mice. It was also observed that inulin+DMH-treated mice had significantly (p<0.05) decreased colonic pH compared with lactulose +DMH treated mice while no significant difference was found in the colonic mass. Short chain fatty acid mainly butyric acid increased significantly (p<0.05) in inulin+DMH and lactulose+DMH-treated mice compared with DMH-only-treated mice. Thus, it can be concluded that probiotic inulin had better anticarcinogenic property than lactulose in reducing the DMH induced colonic alterations.