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Lactiplantibacillus plantarum TCI999 Probiotic Promoted Hair Growth and Regulated Gut Microbiome: Double-Blind, Placebo-Controlled Trial

Chia-Hua Liang, Yung-Hsiang Lin, Shu-Ting Chan, Yung-Kai Lin, Chi-Fu Chiang

Lactiplantibacillus plantarum is widely used as a probiotic and had increase hair growth in vitro. However, it is still unclear whether L. plantarum can improve hair loss and gut microbiome in clinical trial. The purpose of this study is to examine the effect of L. plantarum on inhibiting hair loss, strengthening hair roots, improved gut microbiome. TCI999 (L. plantarum) was used to treat human Hair Follicle Dermal Papilla Cells (HFDPC), and examine mitochondrial activity and viability of hair follicle cells, and examined hair follicle growth inhibition-related genes (SRD5A1, AR and TGF-β). Additionally, 50 subjects were recruited, and divided into a placebo group and TCI999 group. It was taken once a day for 12 weeks, followed by hair testing, hair-related genes analysis, collection of hair loss and questionnaires. The results showed TCI999 significantly increased mitochondrial activity and hair cell growth, and significantly decreased SRD5A1, AR and TGF-β genes in vitro. Taking TCI999 for 12 weeks significantly increased hair root diameter, improving hair loss as well as scalp redness compared to the placebo group. In addition, TCI999 decreased the pro-inflammatory bacterial phase (Negativicutes, Gammaproteobacteria, Verrucomicrobia, Deltaproteobacteria, and Fusobacteria) and increased the anti-inflammatory bacterial phase (Actinobacteria, Bacteria, Clostridia). Thus, TCI999 can increase hair growth and improve gut microbiome.