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WWOX Drives T Leukemia Cell Maturation via IκBα/WWOX/ERK Signal Pathway

Nan-Shan Chang

Forced differentiation therapy has been shown to be effective in suppressing promyelocytic leukemia cell growth and other types of cancer cells in patients. A combination of calcium ionophore and phorbol ester is effective in inducing terminal maturation of T-cell acute lymphoblastic leukemia (T-ALL), in which it requires the signaling of IκBα/WWOX/ERK. While WWOX is generally regarded as a tumor suppressor, this editorial view addresses the critical role of WWOX phosphorylation at Ser14 and de-phosphorylation at Tyr33 that drives T-ALL maturation.