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Thyroid surgery, İONM and sugammadex sodium relationships: Benefits in sugammadex sodium using for IONM

Turgut Donmez

Introduction: One of the most important complications in thyroid surgery is vocal cord paralysis as a result of recurrent laryngeal nerve (RLN) injury. While unilateral injury of the nerve can be tolerated by the patients, bilateral nerve paralysis might results in as severe complications as death. The surgeon must use a strictly standardized intra operative neuro monitoring technique (IONM) to succeed a good, well-quality monitoring and safe-surgery in order to prevent injury to RLN and save its functions. But, the half-life of general anesthetic drugs with neuromuscular blockade effect which are used during operation are closely related to affectivity and reliability of IONM. We aimed to detect nerve conduction by using TOF-Guard neuromuscular transmission monitor and provide a more reliable IONM after administering sugammadex sodium (bridion) which antagonizes neuromuscular blockade of the anesthetic drug.

Background: Following the sedation, the patient was ventilated for two minutes and intubated with a protected endotracheal tube (7 to 7.5 mm inward measurement) with a surface cathode fixed 2 cm better than the sleeve (Dr. Langer Laryngeal cylinder anode). The cement cathodes, 6-7 or 7.7-9 mm size, were circularly folded over the endotracheal tube, 10-20 mm over the sleeve (expand), approximating vocal strings. The anesthesiologist checked in the event that it was accurately positioned by utilizing a laryngoscope (Fig. 1, A-C). To forestall a short out and an unfriendly impact of the electrical flow, a ground anode was set on the shoulder and associated with the laryngeal cylinder. The right settlement of the anodes around vocal ropes was checked by recording engine activity possible reaction in the neck to the electrical motivation on laryngeal nerve.

Method:- 20 patients who underwent total thyroidectomy operation in our surgery department between January 2017 and March 2017 were involved into the study. All the patients were intubated following anesthesia induction with propofol 1.5 mg/kg; rocuronium 0.6 mg/kg; remifentanil 0.25 microgram/kg/min and mechanically ventilated at Vc mode. Anesthesia maintenance was provided with remifentanil of 0.25 microgram/min, sevoflurane of 0.8 mac, and air-o2 combination of 4 lt/min. Following the intubation, the TOF-Guard neuromuscular transmission monitor was placed on left hand and TOF was measured and recorded. 100 mg of bridion was administered intravenously just before the surgeon start thyroid gland resection. Following bridion injection, TOF response at 1st, 2nd, 3rd and 4th minutes were measured and recorded. If the response was over 90%, then the surgeon was let to use neuromuscular monitoring device. Vocal cord examinations were done in all the patients by an ear-nose-throat specialist on the 1st post-operative day. Age, gender, recurrent laryngeal nerve conduction speed before and after excision, BMI, surgery time, hospital stay duration, nerve conduction response duration following drug injection and complications were analyzed. A 3-to 4-cm Kocher entry point was made and the platysma with subplatysmal folds were raised superiorly and poorly with the assistance of the electrocautery. The lash muscles were withdrawn for sidelong presentation of the center thyroid vein, if present, to be partitioned. Every little vessel were blocked with a vessel-fixing gadget. The electrocautery was utilized to dismember the pyramidal projection and the isthmus. During complete thyroidectomy, the vagal nerve was found on the left side first. The vagus nerve was found by dismembering the region between carotid conduit and jugular vein. The vagus nerve (VN) was distinguished under direct vision and the nonappearance of the sign was watched. At that point, a sugammadex sodium (2mg/kg) bolus was controlled intravenously. Following sugammadex sodium infusion, TOF records of first, second, third and fourth minutes were estimated and at where the reaction was greater than 90%, the neuromuscular checking gadget was begun to be utilized.

Results: None of the patients developed nerve-related complications. The mean age was 47.6±11.82 years and mean BMI was 28.745±3.20. The mean operation time was 52.65±5.51 min. There wasn’t any significant difference in neither right nor left RLN monitoring values before and after surgery. Following the drug injection, the TOF guard nerve conduction response values were found 23.5±4.90; 69.5±6.86; 88±4.1 and 100, on 1st, 2nd, 3rd and 4th minutes, respectively. The use of an anti-muscle relaxant drug and detecting the presence of nerve conduction with TOF-guard nerve monitor can provide a more reliable IONM and more safe surgery.

Biography: Turgut Donmez was graduated from Istanbul University Cerrahpasa Medical Faculty in 1997 and completed his Residency in General Surgery in 2003 in the same faculty hospital. He has been working at Lutfiye Nuri Burat State Hospital. He has expertise in laparoscopic and thyroid surgery