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The Strategies for Increasing Cordycepin Production of Cordyceps Militaris by Liquid Fermentation

Qiang Zhang, Yi Liu, Zhibiao Di, Chunchao Han* and Zhenquan Liu

 The aims of this review are to describe the biosynthetic pathway of cordycepin and summarize the strategies for increasing cordycepin production of Cordyceps militaris by liquid fermentation. In recent years, researchers made remarkable progress in cordycepin production. They focused their attention on the three aspects to improve cordycepin production: strain improving, optimizing ingredients of medium and optimizing culture conditions. This review might be helpful for understanding of cordycepin boisynthesis and increasing the production of cordycepin.