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The MET Receptor Tyrosine Kinase as a Therapeutic Target in Multiple Myeloma

Christine M Stellrecht, Shadia Zaman and Varsha Gandhi

Multiple Myeloma (MM) is a progressive and debilitating B-cell disorder typified by the accumulation and dissemination of malignant plasma cells in the bone marrow which subsequently induce osteolytic lesions.Despite recent advancement of new therapies for MM, patients ultimately develop drug resistanceand succumb to the disease. This highlights the need to increase our understanding of the disease and to identify new myeloma targets for drug development.