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T11TS Induced Modulation of Macrophages Associated Cytokines TNF- α,VEGF and Apoptototic Protein Bax, Bcl2 Abrogates Tumor Cells in In vitro Grade I,II Human Glioma

Pankaj Kumar, Sirshendu Chatterjee, Samarendra Nath Ghosh, Sagar Acharya, Annpurna Kumari, Suhnrita Chaudhuri and Swapna Chaudhuri

T11 target structure (T11TS), a membrane glycoprotein has been documented with anti-neoplastic activity in glioma bearing animal model in our lab. In this study, we have evaluated the phagocytic potential, expression of VEGF, TNF-α in T11TS treated and untreated macrophages in all four grades of glioma. The data indicates the significant enhancement of phagocytosis in T11TS treated macrophages of Grade I and II glioma. There was significant upregulation in TNF-α and significant down-regulationin VEGF expression in T11TS treated macrophages in grade I and II glioma.We alsoattempted to know any possible apoptotic role of T11TS in tumor cell by comparing Bax and Bcl2 in treated and untreated tumour cell of all four grades. We found significant up-regulation in Bax expression and down-regulation in Bcl2 expression of grade I and II glioma. The outcome may help in pushing this molecule into pharmaceutical domain.