select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='29871' and ad.lang_id='8' and j.lang_id='8' and vi.lang_id='8'
आईएसएसएन: 2161-0401
Stefania Costa, Irene Rugiero, Elena Tamburini, Alessandro Medici, Giancarlo Fantin and Paola Pedrini
The synthesis of hydroxy-androstane-1,4-diene-3,17-dione derivatives (2a-d) by biotransformations with Pseudomonas alcaliphila of bile acids (1a-d) was reported. The scale-up of addition of deoxycholic acid (1a), cholic acid (1b), and chenodeoxycholic acid (1c) (1 g/L until 10 g/L) to the culture broth of P. alcaliphila switches the degradation process to the synthesis of 12β-hydroxy-androstane-1,4-diene-3,17-dione (2a, 95%), 7α,12β-dihydroxy-androstane- 1,4-diene-3,17-dione (2b, 52%), and 7α-hydroxy-androstane-1,4-diene-3,17-dione (2c, 23%) Also hyodeoxycholic acid (1d) was transformed by P. alcaliphila to 6α-hydroxy-androstane-1,4-diene-3,17-dione (2d) with as much good yields (83%) but with lower concentration (1 g/L) in the culture broth.