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SYNTHESIS, ANTIBACTERIAL, AND ANTIFUNGAL EVALUATION OF NOVEL MANNICH BASES COMPOUNDS CONTAINING OXADIAZOLE AND PYRAZOLE MOIETIES

Maliki Reddy Dastagiri Reddy, Aluru Raghavendra Guru Prasad, Yadati Narasimha Spoorthy, Lakshmana Rao Krishna Rao Ravindranath

Purpose: To synthesize novel series of compounds containing 1,3,4-oxadiazole and pyrazole-3- one moieties in good yields and to evaluate the antimicrobial activity of title compounds. Methods: Title compounds were characterized by IR, 1H NMR and mass spectra and evaluated for their antimicrobial activities against certain selected gram-positive bacteria, gram-negative bacteria and fungi by disk diffusion method and broth dilution method. Results: Fluoro, chloro, bromo, nitro, morphonilyl, piperizynyl, N-methylpiperizine substituted compounds (VII c, d, e, f, i, j and k) showed more antimicrobial activity against than other compounds of the series. Conclusion: Antimicrobial activity was expressed as the corresponding minimum inhibitory concentration (MIC). The compounds have demonstrated considerable antibacterial and antifungal activities.