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SARS-CoV-2: Genome, New Variant and Risk of Infection in Immunized Individuals

Edy Parwanto

The COVID-19 outbreak was caused by SARS-CoV-2. This situation is concerning because it has created uncertainty and has become a world problem. Regarding the COVID-19 outbreak, a genomic analysis of SARS-CoV-2 has been carried out. The genome of SARS-CoV-2 contains 29.903 nucleotides (nt). The SARS-CoV-2 genome consists of the: 5’ UTR, ORF 1ab gene, S gene, ORF 3a gene, E gene, M gene, ORF 6 gene, ORF 7a gene, ORF 7b gene, ORF 8 gene, N gene, ORF 10 gene and 3’ UTR. It has been reported about the discovery of a new variant namely B.1.1.7 (20I/501Y.V1), B.1.351 (20H/501Y.V2), B.1.429 (452R.V1), P.1-lineage (20J/501Y.V3). Consequently, the presence of the new variant of SARS-CoV-2 described above affects the risk of infection in immunized individuals.