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अमूर्त

Role of lrp in the Pseudomonas Aeruginosa Small Colony Formation

Dinesh Diraviam Sriramulu

Formation of small colonies and slow growth are among common features of Pseudomonas aeruginosa isolated from the lung of cystic fibrosis (CF) patients. A slowgrowing CF lung isolate strain C that was complemented with the whole-genome cosmid library, created from an environmental isolate, revealed the role of leucine-responsive regulatory protein on the colony size, the growth and the proteome profile. Sequence analysis of lrp and its homologues in strain C revealed a mutation in the homologue PA3965 compared to the respective sequence of PAO. In addition to the regulation of enzymes involved in amino acid biosynthesis and metabolism, Lrp seemed to regulate the expression of chaperones (DnaK, GroEL and GroES) and the suppressor protein DksA.