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Relationship between the Neutrophil to Lymphocyte Ratio (NLR) and International Prostate Symptoms Score (IPSS) in Men with Benign Prostatic Enlargement (BPE) in Hospital Raja Perempuan Zainab II (HRPZ II)

Muhd Zaki Azre Redzuan*

This study aimed at investigating the potential use of the Neutrophil to Lymphocyte Ratio (NLR) as a biomarker for assessing the severity of lower urinary tract symptoms in patients with prostate disease. The study included 363 patients with Benign Prostatic Enlargement (BPE) and compared their NLR values with clinical and laboratory parameters, including the International Prostate Symptom Score (IPSS), Prostate-Specific Antigen (PSA) level, and maximum u rinary flow rate (Q_max).

The results showed that NLR values were significantly higher in patients with more severe lower urinary tract symptoms, as measured by the IPSS score. Furthermore, NLR values were positively correlated with total white cell count and neutrophil count, and negatively correlated with lymphocyte count in BPE patients. The study also found a positive correlation between NLR and PSA levels in BPE patients attending the clinic.

The association between NLR and prostate disease can be explained by the role of inflammation and immune function in the pathogenesis of prostate disease. Chronic inflammation has been linked to the development and progression of BPH and prostate cancer, and neutrophils are one of the key immune cells involved in the inflammatory response. Additionally, lymphocytes play a critical role in the adaptive immune response, which is essential for recognizing and eliminating cancer cells. The study suggests that NLR may be a useful biomarker for assessing the severity of lower urinary tract symptoms in patients with prostate disease. However, the performance of NLR as a predictor of prostate disease may be influenced by external factors such as age, comorbidities, and medication use, and further research is needed to better understand the relationship between NLR and aging. In conclusion, the findings of this study highlight the potential use of NLR as a biomarker for assessing the severity of lower urinary tract symptoms in patients with prostate disease.