जर्नल ऑफ़ प्रोटियोमिक्स और बायोइनफार्मेटिक्स
खुला एक्सेस

अमूर्त

Proteomic Analyses of Proteins Differentially Expressed in Recurrent and Primary Pterygia

Takashi Kanamoto, Nazariy Souchelnytskyi, Ryotaro Toda, Ulfah Rimayanti and Yoshiaki Kiuch

We describe a proteomic approach to identify proteins which may be involved in the recurrence of pterygia. Tissues from a recurrent pterygium and from a primary pterygium were surgically resected and were analyzed by proteomics to identify proteins that were significantly up- or down-regulated. The proteins showing significant differences in the two tissues were identified by mass spectrometry. Eleven proteins were differentially expressed; seven proteins were up-regulated and four proteins were down-regulated in the recurrent pterygium. The identified proteins are known to regulate cell cycle, cell organization, extracellular matrix, cholesterol metabolism, and cell signaling. Up- and down-regulation of proteins for cellular signaling are most likely involved in the recurrence of pterygia.