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खुला एक्सेस

अमूर्त

Proteome Profile of Zebrafish Brain Based on Gel LC-ESI MS/MS Analysis

Sachin Kumar Singh, Komarla Setty Rakesh, Kalidoss Ramamoorthy, Attluri V Pardha Saradhi and Mohammed Mohammed Idris

The zebrafish (Danio rerio) is the extensively used alternate vertebrate model animal for understanding the brain function, development and evolution. Detailed brain proteome map of zebrafish is still not known inspite of its broad usage in developmental and neurological studies. We present here the large scale proteome profile of the zebrafish brain at the normal condition based on gel LC ESI MS/MS analysis. A total of 8475 different proteins details were identified based on this study with less than 1% false positive rate. All the proteins details obtained from this study were duly submitted to the database for validation and obtained accession numbers. The various proteins identified in this study were found to be involved in different biological activities, neurological functions and network pathways. With the availability of genomics information, this extensive study of proteomic profile of zebrafish brain tissue provided a complete view and details about the various proteins expressed in brain at the basal state. This study can lead to understand various new biomarkers underlying for various biological characteristics like development and neurological disease.