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अमूर्त

Plant Extracts as Solutions to Multi Drug Resistant, Indigofera homblei Bak.f and Martin, Fabaceae, a Plant used in Kenya against Microbial Related Conditions

Omari Amuka, Paul K Tarus, A K Machocho and Ernest K Ruttoh

Multi drug resistance of pathogens to drugs has become a universal problem. The aim the study was to investigate if plants’ natural products could offer alternative solutions to the problems. Roots of the plant were collected from Keiyo District; air dried in the shade then ground into fine powder and extracted with methanol, analytical grade, which eventually evaporated using a rotor evaporator. Known amount of the resultant material was measured and dissolved using 1 ml of dimethyl sulphoxide and topped with deionized water to form a known concentration. Serial dilutions of the drug were further made. Disc diffusion methods was used in the microbial studies with registered microorganisms at the National Public Health Laboratory, Nairobi. There were indications that the plant’s extracts possessed reasonable antimicrobial activities. The other portion of the extracts was subjected to wet bench studies which revealed the presence of several classes of compounds that are known to have curative properties. It was evident that the local inhabitants are justified to use the plant in the management of various that inflict them and it was recommended that the plants extracts cytotoxicity in higher animals be evaluated so as to justify its continued used in folklore medicine. It was also recommended that the compounds in the plant be further elucidated to assess their potential as sources of new compounds that could be used by the pharmaceutical concerns in new drugs development.