जनरल डेंटिस्ट्री जर्नल
खुला एक्सेस



Felix Essiben, Junie Annick Metogo Ntsama, Esther Juliette Ngo Um Meka, Etienne Belinga, Xavier Junior Ayissi Ngono, Wilfried Loïc Tatsipie, Josiane Salie Dimele, Veronique Mboua Batoum, Valere Mve Koh

Background: HELLP syndrome is a serious gravido-puerperal complication of preeclampsia. Moreover, it is associated with significant maternal and perinatal morbidity and mortality, such as blood transfusion, which were 8 times higher in patients with HELLP syndrome than in isolated PES and thus most often requiring immediate termination of the pregnancy. We therefore conducted a study on the factors associated with HELLP (Hemolysis Elevated Liver Enzymes and Low Platelets count) syndrome [SH] in patients with severe pre-eclampsia in three (03) hospitals in Yaoundé. Methodology: We conducted a case-control study of women admitted with severe pre-eclampsia who had or had not developed HELLP syndrome; during a period from May 2019 to May 2021 in three (3) 2nd category hospitals in Yaoundé. The sampling was consecutive and not exhaustive. We included patients with a complete medical record. Statistical analysis was done using the S.P.S.S.23.0 software. The significance level was set at 0.05. Results: A total of 19 cases of HELLP syndrome were recruited and matched to 60 controls during the study period, i.e. 1 case for every 3 controls. The univariate analysis identified the following as factors favoring HELLP syndrome The univariate analysis identified the following factors as favouring HELLP syndrome: age group [15-20 years], follow-up in a health centre, antenatal visits by nurses and epigastralgia. And as a protective factor calcium supplementation. After multivariate analysis multivariate analysis, calcium supplementation was protective against HELLP syndrome OR=0.20 IC95% (0.05-0.81) p= 0.025. In addition, having a nurse as a provider of antenatal visits was significantly associated with the occurrence of HELLP syndrome, OR=5.37; IC95% (1.37-20.44). Conclusion: Maternal and fetal mortality associated with severe forms of pre-eclampsia remains high, hence the need for continuous improvement in its management. Calcium supplementation during pregnancy has significantly limited the occurrence of severe forms such as HELLP syndrome.