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Nodular Regenerative Hyperplasia: A Rare Complication of Treatment with Thiopurines in Patients with Crohn’s Disease

Testa Anna, Terracciano Luigi, D’Armiento Maria Rosaria, Imperatore Nicola, Nardone Olga Maria, Rispo Antonio and Castiglione Fabiana

A 25-year-old male with ileal pre-anastomotic recurrence of Crohn's disease (CD) experienced nodular regenerative hyperplasia (NRH) secondary to treatment with azathioprine (AZA). The subject showed increase in cholestasis indices and a reduction in platelets. The diagnosis of NRH was established by liver biopsy; outcome was favourable after treatment discontinuation, with complete normalization of liver function tests within less than one year.