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MHC Class 1-Related Chain A and B Ligands are Differently Expressed in Cancer Cell Lines

Oremo JAA, Zhang Xiao and Zhu Sha

The MHC class I related chain A and B have been of much interest in the recent past MHC class 1 related gene A/B (MICA/B) are ligands of the NKG2D, which is an activating receptor expressed on T and NK cells (NK cells are effector cells of the innate immune system and their functions are regulated by a number of killer cell-inhibitory and -activating receptors.).Their expression on normal tissues is highly restricted but in the event of tissue transformation and infected cells, MICA/B expression is up-regulated leading to NK killing activity. MICA/B are shedded in the serum of cancer patients (sMICA/B) whereby sustained expression of this MIC affects the killing activity of NK cells and T cells. In this summary review we look at how differently MIC A/B is expressed in Cancer cell.