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Mesenchymal Progenitor Cells from Different Sources and their Potential to Differentiate In Vitro into Muscle Cells

Ranjith Kumar Indarapu, Leela Krishna and Subhadra Dravida

The field of regenerative medicine requires a reliable source of therapeutic cells in the context of muscular dystrophies. Cell therapies are among the treatment options being considered with the advances in stem cells and scaffolding domain. Umbilical cord tissue, Dental pulp and adipose tissues are abundant sources for clinical grade mesenchymal stem cells. These cells can differentiate into multiple lineages. The isolation, characterization, transdifferentiation, cell- gel formations and clinical applications of stroma derived mesenchymal progenitors are compared with each other source to evaluate the regenerative capability invitro. Dental pulp derived mesenchymal stem cells showed more propensity towards myogenic transdifferentiation although the abundance of the source and ease of higher cell yield was observed with cord and adipose tissue.