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Meningeal Infiltration of Chronic Myelomonocytic Leukemia

Inga Mandac Rogulj, Slobodanka Ostojic Kolonic, Delfa Radic Kristo and Ana Planinc-Peraica

Chronic Myelomonocytic Leukemia (CMML) is a hematologic malignancy considered a subtype of Myelodysplastic Syndrome (MDS)/Myeloproliferative Disease (MPD). According the World Health Organization (WHO) two subtypes of CMML, CMML-1 and CMML-2 are defined depending on the percentage of blasts in Bone Marrow (BM) and Peripheral Blood (PB). The clinical presentation is variable, but the majority of patients present with fatigue, weight loss, fever, night sweats and splenomegaly, less often skin infiltration or serous effusions. Meningeal leukemic involvement is rarely a presenting feature of CMML. We are reporting a case of 67-year old male with central nervous system involvement of CMML.