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Mast cell leukemia

Lucas Aarron

Mast cell leukemia is a particularly aggressive subtype of acute chronic myelocytic leukemia that sometimes occurs de novo but can, rarely, evolve from transformation of chronic chronic myelocytic leukemia into the more aggressive acute chronic myelocytic leukemia. During a small proportion of cases, acute mastocyte leukemia may evolve from a more progressive sort of systemic mastocytosis. The diagnosis of acute mastocyte leukemia by the WHO criteria includes the need for a prevalence of 20% neoplastic mast cells in marrow and 10% in blood. If the mast cells represent but 10% of blood cells, the tumor is named "aleukemic" mastocyte leukemia.