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Industrial Scope of Cyclodextrins in Pharmaceuticals Products: A Review

Riffat Latif, Irum Latif, Rizwan Khalid, Maida Minahil Mushtaq, Zulcaif Ahmad, Naveera Nazir

Cyclodextrins (CDs) belongs to a class of novel excipients used in pharmaceutical fields and have been studied for almost 100 years. Cyclodextrins have been used in almost 35 above products in pharmaceutical industries. Chemically CDs are macrocyclic oligosaccharides that consist of α-(1,4) linkages of dextrorotatory glucopyranose units which show same biological characteristics as that of their linear counterparts however some physicochemical properties are different. CDs have a hydrophilic and lipophilic cavities in their structures. Because of this property they have ability to make inclusion complexes with lipid soluble drugs. CDs are also used to enhance solubility of water soluble drugs and hence increase the bioavailability of these drugs followed by improved absorption. In this way CDs and their derivatives also attractive for their use in the modification of drug profile. CDs are also considered for their use to convert oil and liquid drugs into microcrystalline and amorphous powders, also used to decrease side effects of API. CDs are important for their non-toxic behavior which aids their importance as an inactive excipient in many pharmaceutical and food additives. By combining with CDs many poor water soluble drugs can be manufactured in dosage forms like parenteral solutions, eye, nasal and ear drops. This review will provides an overview for the utility of CDs in diverse nanotechnology dosage forms like liposomes, niososmes, nanoparticles, microspheres and microcapsules etc