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Induced Pluripotent Stem Cells Restore Function in a Human Cell Loss Model of Open-Angle Glaucoma

Abu-Hassan DW, Li X, Ryan EP, Acott TS and Kelley MJ

The possibilities of novel stem cell therapies to curtail treat, or even cure diseases are enticing, yet safety and functional questions remain prior to clinical use. Currently the stem cell transplantation field for eye diseases is generally defined as being at the pre-clinical or early clinical trials stages. Pre-clinical studies can hopefully eliminate or determine possible transplantation complications prior to human trials. In our manuscript in Stem Cells, we investigated the possibilities of using a personalized cell therapy to treat glaucoma, and in this paper reported two crucial breakthroughs towards this end.