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Immunoproliferative Small Intestinal Disease: Infectious Pathogen Associated Human Lymphoma

Lauge H. Suarez

The term small intestinal immunoproliferative disease (IPSID) is adopted by World Health Organization (WHO) in 1978. This IPSID is a type of lymphoma that occurs in the small intestine in the lymphoid tissue associated with the mucosa. This type of lymphoma is characterized by a large number of plasma cells infiltrated in the intestinal wall. These plasma cells exude alphaimmunoglobulin heavy chains but are not content with any immunoglobulin light chains. Most cases are characterized by the loss of the ability to synthesize light chains and the discharge of defective heavy chains. Its histopathological feature is that lymphocytes and plasma cells infiltrate the wall of the small intestine. Infiltration produces abnormal immunoglobulin (IgA), which is a truncated alpha heavy chain with no light chain component.