select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='42685' and ad.lang_id='8' and j.lang_id='8' and vi.lang_id='8' Identification of Co-inhibitory Receptors PD-1 and TIM-3 on | 42685
इम्यूनोथेरेपी: ओपन एक्सेस

इम्यूनोथेरेपी: ओपन एक्सेस
खुला एक्सेस

आईएसएसएन: 2471-9552

अमूर्त

Identification of Co-inhibitory Receptors PD-1 and TIM-3 on T Cells from Gastric Cancer Patients

Yunhui Zong, Songbing He,Fuliang Chu, Yu Jing, Sally A Hunsucker, Tina Yang, Fengtao You, Sisi Ye, Yafen Li1, Jinle Tang, Huimin Meng, Gangli An,Xingding Zhang, Bozhen Zhang and Lin Yang

The critical role of tumor antigen-specific immune responses to restrain tumor growth in patients with gastric cancer furthers the need to dissect the co-inhibitory pathways involved in tumor infiltrating lymphocyte (TIL) exhaustion/dysfunction. It was previously reported that PD-1 expression was significantly increased on CD4+ and CD8+ T cells from patients with gastric cancer and in gastric cancer tissues, compared to normal donors. In this study, we observed up-regulation of TIM-3 and PD-1 expression on peripheral T cells and up-regulation of CTLA-4, TIGIT, TIM-3 and PD-1 expression on TILs from gastric cancer patients. Furthermore, the percentages of PD-1+/TIM-3+ and PD-1+/TIM-3- peripheral T cells was significantly higher in gastric cancer patients than normal donors, and the percentage of PD-1+/TIM-3+ TILs was significantly higher than the percentage of PD-1+/TIM-3+ peripheral T cells in gastric cancer patients. PD-1+/TIM-3+ cells represent the predominant fraction of TILs. PD-1 blockade enhanced cytokine production and the cytotoxicity of TILs and exhibited a synergistic effect with TIM-3 blockade. Moreover, the expression of PD-1 was associated with the age, tumor size and lymph node metastasis of patients. Collectively, our results suggest that the use of anti-PD-1 blockade in combination with anti-TIM-3 blockade could restore the function of TILs in patients with gastric cancer.

अस्वीकरण: इस सार का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया था और अभी तक इसकी समीक्षा या सत्यापन नहीं किया गया है।
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