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FBXW7 Pathway Functions as a Promising Therapeutic Target of Cholangiocarcinoma

Hui Yang, Lili Chen, Yuxin Chen and Guangwei Wei

Cholangiocarcinomas (CCAs) are a heterogeneous group of rare malignancies originating from the epithelial cells of the biliary tract, which can be classified anatomically as intrahepatic (IHCC), perihilar (PHCC), and distal (DCC) CCA. Although rare, the incidence of CCAs has increased worldwide over the past 3 decades, which may be caused by the following reasons: firstly, diagnosis of CCAs is usually in the 70’s of age, its incidence is inevitably increased with the prosperity of aging society; secondly, more CCAs are detected in recent years because of the development of imagology, especially in developing countries. However, the risk factors of CCAs remain to be confirmed at present. In addition, the 5-year overall survival rate after diagnosis remains low at 10%