क्लिनिकल और सेलुलर इम्यूनोलॉजी जर्नल
खुला एक्सेस

अमूर्त

Exercise-Mediated Immune Protection in Chronic Kidney Disease Decreases Infection and Severe Evolution of COVID-19

Josiano Guilherme Puhle1, Vanessa da Silva Corralo1, Adinei Abadio Soares2, Joao Vitor Kroth3, MarianaMunhoz Gallina3, Matheus Goncalves Cavasin3, Vinicius Ansolin3, Danieli de Cristo4, Angela MakeliKososki Dalagnol4, Debora Tavares de Resende e Silva4*, Gabriela Vidotto Cavallieri5, Renata Calciolari Rossi6

It is constantly sought to understand the different mechanisms of action of the immune system to establish potential efficient therapeutic targets for different clinical situations. Thus, the present study aims to expand the knowledge about the protective effect of physical exercise on the immune system of patients with chronic renal failure, associating it with the incidence of infection by COVID-19. The present study was based on a narrative systematic review of the literature and understands, elucidate, and discuss the subject. The main result found was that regular, moderate-intensity exercise modulates immunological parameters in CKD patients, evidenced by decreased inflammatory factors such as Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-18 (IL-18) and Tumor Necrosis Factor-α (TNFα), and increased Interleukin-10 (IL-10) and Interleukin-4 (IL-4). Decreases in C-reactive protein and intercellular Adhesion Molecule-1 (ICAM-1) were also seen, associated with increased activity of leukocytes, Natural Killer (NK) cells, and CD8⁺ T cells. Based on this, moderate and continuous exercise is a protective therapy for kidney patients, causing a decrease in the risk of morbidity and mortality caused by COVID-19 infection.