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Evaluation of Vitamin D level and Fatigue in Acute Leukemia Patients Undergoing Chemotherapy

JoAnn Liu, Diane Ryan, Tan Wei and Shousong Cao

The aim of this study is to evaluate vitamin D level and fatigue in acute leukemia patients undergoing chemotherapy. Forty one patients with acute leukemia (AL) undergoing chemotherapy were enrolled and 30 patients were prospectively examined the relationship between 25(OH) vitamin D and fatigue. Vitamin D levels were measured and patients with subnormal (< 32 ng/ml) were supplemented with 25(OH) vitamin D. Spearman Correlation Coefficients and Wilcoxon rank sum test were used for the comparison. Vitamin D deficiency and insufficiency in AL patients are similar to the general population. There was no significant correlation (P > 0.05) between vitamin D level and fatigue in the study. Therefore, Vitamin D supplementation may no help to improve fatigue in acute leukemia patients undergoing chemotherapy with vitamin D deficiency. However, Larger samples should be further examined the effect of vitamin D supplementation on fatigue in cancer patients with vitamin D deficiency.