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Evaluation of Hormonal and Biochemical Risk Factors for Benign Prostatic Hyperplasia: A Possible Way for Management and Prevention of Benign Prostatic Hyperplasia

Chinedum Joseph Ndefo, Parker Elijah Joshua*, Eleazar Chukwuemeka Anorue

Objective: To identify some risk factors that contributes to the development and severity of BPH among the elderly in Enugu state, Nigeria.

Study design: One hundred men aged 53 years-85 years were used for the study; the study was divided into two groups consisting of 50 male patients diagnosed with BPH and 50 healthy subjects.

Methods: Twenty millilitre of whole blood samples were collected from each patient and the following parameters were investigated; oestrogen, testosterone, lipid profile, PSA, PAP, TAP, electrolyte concentration and antioxidant biomarkers.

Results: It was found that increase in PAP, TAP, total cholesterol, TAG, LDL, oestrogen, potassium and sodium and decrease in levels of catalase, GP_x, selenium, HDL and testosterone are risk factors for the development and severity of BPH.

Conclusions: In view of this, modifiable lifestyles can be adopted for the prevention, management and treatment of BPH.