select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='8788' and ad.lang_id='8' and j.lang_id='8' and vi.lang_id='8' Epigenetic Re-Programming during Mammalian Preimplantation E | 8788
जर्नल ऑफ़ फर्टिलाइजेशन: इन विट्रो - आईवीएफ-वर्ल्डवाइड, रिप्रोडक्टिव मेडिसिन, जेनेटिक्स और स्टेम सेल बायोल

जर्नल ऑफ़ फर्टिलाइजेशन: इन विट्रो - आईवीएफ-वर्ल्डवाइड, रिप्रोडक्टिव मेडिसिन, जेनेटिक्स और स्टेम सेल बायोल
खुला एक्सेस

आईएसएसएन: 2375-4508

अमूर्त

Epigenetic Re-Programming during Mammalian Preimplantation Embryogenesis and PGC Development

Fei Teng and Qi Zhou

Epigenetic programming and reprogramming, by means of DNA methylation and histone modifications etc., control the mammalian development to a large extent. They are also artificially altered for cell fate conversion and regeneration. Though epigenetic modifications change with slow dynamics during somatic cell lineage differentiation, they undergo a genome-wide dramatic change with extensive DNA de-methylation and histone modification during two specific time windows, the early embryogenesis and the Primordial Germ Cell (PGC) development stage. Here we reviewed these global epigenetic reprogramming occurred during normal development, mainly focusing on DNA methylation, histone modification and X-chromosome inactivation. Epigenetic reprogramming participates in many key biological processes such as genomic imprinting, X-chromosome inactivation, gene expression regulation and tumorigenesis and genome stability. Understanding the mechanisms of epigenetic reprogramming during the early embryogenesis and PGC formation would facilitate our knowledge of the developmental process and disease progress.

अस्वीकरण: इस सार का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया था और अभी तक इसकी समीक्षा या सत्यापन नहीं किया गया है।
Top add_chatinline();