select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='42838' and ad.lang_id='8' and j.lang_id='8' and vi.lang_id='8' In Vivo Study of Epithelial Adhesion via E-Cadherin-and#946; | 42838
सेल संकेतन जर्नल

सेल संकेतन जर्नल
खुला एक्सेस

आईएसएसएन: 2576-1471

अमूर्त

In Vivo Study of Epithelial Adhesion via E-Cadherin-β- and α- Catenin-small GTP-Binding Proteins under T3 Regulation

Galetto CD, Izaguirre MF and Casco VH

Since the middle of last century there have been a plethora of studies trying to comprehend the fine control of adhesive contacts involved in establishment, maintainance and remodelling of epithelial architecture during animal development and adulthood. Depending on the experimental model, surprising and even contradictory data have been obtained. Among these, the in vivo systems outperform in vitro models in terms of understanding the animal biology.

It is known that thyroid hormones (THs) modulate energy metabolism, growth and development by independent mechanisms. Thyroid calorigenesis is influenced predominantly via thyroid hormone receptors (TRs) that mediate synthesis of mitochondrial respiratory complexes and cell membrane sodium-potassium ATPase; whereas it is debate matter if many of the TH effects over epithelial development are principally mediated via growth factors, TRs or transmembrane proteins.

Present work presents molecular evidences that T3 modulates the epithelial adhesive potential during gut remodeling in X. laevis development, differentially activating E-cadherin, β-catenin and α-catenin genes, and downstream, modulating small GTP-binding proteins involved in adhesive epithelial properties.

अस्वीकरण: इस सार का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया था और अभी तक इसकी समीक्षा या सत्यापन नहीं किया गया है।
Top