जर्नल ऑफ़ क्लिनिकल टॉक्सिकोलॉजी
खुला एक्सेस
आईएसएसएन: 2161-0495
आईएसएसएन: 2161-0495
Debasish Dutta, Richmond Ronald Gomes, FM Monjur Hasan, Seema Saha, Mamun Newaz
Background: Ingestion of copper sulphate is a common mode of poisoning in the Indian subcontinent. Cases are mainly suicidal in nature. The clinical course of the copper sulphate intoxicated patient is often complex involving intravascular hemolysis, jaundice and renal failure. The treatment is mainly supportive. Mortality is quite high in severe cases if treatment is not adequate and prompt.
Methods and materials: This cross sectional, observational, prospective study was conducted on 50 patients with acute copper sulphate poisoning attended in Medicine department of Khulna Medical College Hospital from January 2020 to June 2020.
Results: Almost all patients of copper sulphate poisoning, presented with gastrointestinal symptom like nausea 50 (100%), vomiting 49 (98%) and abdominal pain 26 (52%). Development of anemia 17 (34%) and signs of hepatotoxicity like jaundice 18 (36%), signs of dehydration 7 (14%), features of shock 8 (16%) and chest findings like tachypnoea, crepitations 9 (18%) were common. On investigation, Hemoglobin percentage below 10 gm/dl in 12 (24%), neutrophillic leukocytosis 18 (36%), Platelet count below 100000/cu mm blood in 3 (6%). features of hemolysis 16 (32%), haemoglobinuria 17 (34%) and haematuria 15 (30%), S. bilirubin was elevated in 23 (46%) of patients. Serum ALT level was elevated in 17 (34%) of patients of which 13 (26%) were found as moderate to severely raised both serum creatinine and blood urea were elevated in 16 (32%) of patients.
Conclusion: Acute copper sulphate poisoning is common in our country which is mainly suicidal in nature. As death occurs due to multi organ failure, while gastrointestinal, intravascular hemolysis, hepatic and renal toxicities significantly contribute to it. Management in high dependency unit is also required.