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Comment-Protein Contact Networks: A New Framework for Structural Biology

Luisa Di Paola

Protein structure information is not sufficient to predict biological functionality. Among different approach of analysis, protein contact networks provide a previliged point of view through the recognition of proteins as complex networks: the invariant of the networks are related to different properties of protein molecules.

Folding dynamics and allosteric binding find new and detailed description within this framework, pointing at this methodology as one of the most promising in the perspective of big data analysis of whole proteomes.