हेपेटोलॉजी और गैस्ट्रोइंटेस्टाइनल विकारों के जर्नल
खुला एक्सेस

अमूर्त

देर से शुरू होने वाले अल्जाइमर रोग (एडी) में रक्त माइलोसाइट्स और मस्तिष्क के ऊतकों में कोशिका भित्ति की कमी वाले माइकोबैक्टीरिया (सीडब्ल्यूडीएम) का औषधि विकास में नए दृष्टिकोणों के लिए निहितार्थ

विलियम चेम्बरलिन, एंड्रयू टाई, क्रिस्टोफर फाउलर, लॉरेंस वार्ड, जॉन ऐटकेन

Introduction: The presence of cell wall deficient Mycobacteria (L-Form) infections in macrophages and Alzheimer brain tissue is not currently recognized.

Methods: Elderly subjects were selected from the Australian Imaging, Biomarker and Lifestyle study of ageing and grouped as MCI, AD and cognitively normal. Blood buffy coats were cultured and stained using new methods. Histologic slides from archived AD brains were stained for the presence of Mycobacteria L-forms.

Results:

MCI=36/36 blood cultures positive

AD=14/14 positive

Elderly controls=52/52 positive

AD Brain Tissue=10/10 samples positive for CWDM

Conclusions: Elderly people have Mycobacteria L-forms in blood macrophages. Patients with Alzheimer’s disease have what appears to be the microbe in their brains surrounded by biofilm. Members of the genus Mycobacterium join the growing list of microbes associated with AD. Age related immune senescence may enable opportunistic microbes to trigger neuro-inflammation and become pathogenic.