select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='87145' and ad.lang_id='8' and j.lang_id='8' and vi.lang_id='8' Case Report of Xeroderma Pigmantosum with Multiple Malignant | 87145
कैंसर विज्ञान और अनुसंधान जर्नल

कैंसर विज्ञान और अनुसंधान जर्नल
खुला एक्सेस

आईएसएसएन: 2576-1447

अमूर्त

Case Report of Xeroderma Pigmantosum with Multiple Malignant Lesions , Present in Siblings Linking it to Genetic Aspect of the Disease, and PossibleTreatments.

Dipen Mistry

Being a Geno dermatosis, photosensitive disorder XERODERMA PIGMANTOSUM (XP) is a rare autosomal recessive disorder. Patient with XP commonly presented with an interactable and dermatological disease. Patients with XP are prone to cutaneous, mucosal malignancies and ophthalmic complications. Reason being inability to repair the ULTRAVIOLET (UV) radiation dispensed damage to Deoxyribo Nucleic Acid (DNA), genetic nature of disease is revealed. Not only genetic but environmental factor plays big role in course of disease. In XP cutaneous and mucosal basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) or melanoma is most common. XP characterized with sever sunburns, development of many freckles at early age, rough surfaced wart like growths, cutaneous and mucosal malignancies, blistering, telangiectases, ophthalmic manifestations, limited growth of hair on chest and legs and dry skin. 45 to 60% patients of XP were observed to be developing malignant skin neoplasm in different studies. Compare to normal controls Robbins has shown that incident of internal neoplasm in XP patient was 10-20 times higher. Angiosarcoma and Fibrosarcoma have also been reported.

अस्वीकरण: इस सार का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया था और अभी तक इसकी समीक्षा या सत्यापन नहीं किया गया है।
Top