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Biosynthesis of Silver Nanoscale Particles Using Spirulina platensis Induce Growth-Inhibitory Effect on Human Breast Cancer Cell Line MCF-7

Chandrababu Rejeeth, Bojan Nataraj, Raju Vivek and Marimuthu Sakthivel

A biological method was used to synthesize stable silver nanoparticles that were tested against MCF-7 cells are reported. The structure and percentage of synthesized nanoparticles was characterized by using ultraviolet spectrophotometry, X-Ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy methods. The zeta potential value of -36 mV revealed the stability of biosynthesized AgNPs. The in vitro screening of the AgNPs showed potential cytotoxic activity against human breast cancer cell and normal breast epithelial cells the inhibitory concentration (IC50) were found to be 20, 40, 60 and 80 μg/ml for AgNPs against MCF-7 and HBL-100 cells at 24 and 48 h incubation respectively. An induction of apoptosis was evidenced fluorescence microscopy. These results suggest that AgNPs may exert its anti proliferative effects on breast cancer cell line by suppressing its growth, arresting the G0/G1-phase, reducing DNA synthesis.