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Anti-diabetic and Anti-cholesterolmic effects of bittergourd(mommordica charantia Linn) fresh fruit juice metabolites to cure Alloxan Monohydrate induced Type-1 diabetes in Albino Rats

Kumari Shachi, Sanjeev Kumar*, Nayan Kumar Prasad

In the present study an effort has been made to assess the hypoglycemic and anti–cholesterolmic activity of better gourd juice in alloxan monohydrate induced experimental animal model. Rats were acclimatized for 7 days in lab temperature. All animals were given standard water and pellet diet. Diabetes was induced in rats with the help of alloxan monohydrate (120 mg/kg body weight). After alloxan monohydrate injection rats were separated and treatment started with fresh better gourd juice and insulin. A marked rise in fasting blood glucose as well as serum cholesterol level were observed in diabetic control rats when compared to normal control rats. Antihyperglycemic and anti–cholesterolmic activity observed in bittergurd juice administered rats on 7th,14th,21th and 28th days post treatment.Anti–hyperglycemic and anti–cholesterolmic activity was found more effective than that of insulin treatment group. It is hope that present investigation will be helpful in establishing a scientific basis for anti–diabetic and Anticholesterolmic effects.