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A Rare t (8;9;22)(p21;q34;q11.2) Three Way Philadelphia Variant in Chronic Myeloid Leukemia

Pankaj Gadhia and Salil Vaniawala

Background: Chronic myeloid leukemia (CML) is characterized by Philadelphia (Ph) chromosome. The Ph detected by karyotyping in 90% CML but 5-10% may have variant translocation where another chromosome addition to chromosome # 9 and 22. The aim of present report is to describe a rare three-way translocation with rarely describe 8p21 breakpoint. Case report: Retrospective cytogenetic database between March 2104 and February, 2015 was searched for CML cases along with variant translocation. Out of 732 confirmed CML, one male patient with 22 year age showed a variant translocation as 46,XY,t(8;9;22) (p21;q34;q11.2). Conclusion: A rare three-way translocation of chromosome 8, 9 and 22 was detected with cytogenetic and Dual Fluorescence In Situ Hybridization technique (D-FISH) as novel breakpoint at 8p21 which was earlier reported by Abe et al., (1989) before 26 years.